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Loin pain hematuria syndrome, or LPHS, is the combination of debilitating unilateral or bilateral flank pain and microscopic or macroscopic amounts of blood in the urine that is otherwise unexplained. Loin pain-hematuria syndrome (LPHS) is a poorly defined disorder characterized by recurrent or persistent loin (flank) pain and hematuria that appears to represent glomerular bleeding. Most patients present with both manifestations, but some present with loin pain or hematuria alone. Pain episodes are rarely associated with low-grade fever and dysuria, but urinary tract infection is not present. The major causes of flank pain and hematuria, such as nephrolithiasis and blood clot, are typically not present. Renal arteriography may suggest focally impaired cortical perfusion, while renal biopsy showed interstitial fibrosis and arterial sclerosis.〔http://www.uptodate.com/contents/loin-pain-hematuria-syndrome UpToDate® Evidence Based Clinical Support Database Dec 10th, 2014: Hebert, LA. Loin pain-hematuria syndrome〕 The pain is typically severe, and narcotic therapy is often prescribed as a way to manage chronic pain. Sleep can be difficult because the supine position increases pressure on the flank. The onset of pain is often associated with nausea and vomiting, making pain management by oral opiates complicated.〔 ==Prevalence== LPHS is listed as a rare disease in the US National Institute of Health Rare Diseases database.〔http://rarediseases.info.nih.gov/〕 While exact numbers worldwide are not available, the primary LPHS research clinic located in Ohio has over 200 patients. In addition, several hundred other patients have been reported in one study as of 2006.〔Spetie DN, Nadasdy T, Nadasdy G, et al., Proposed Pathogenesis of idiopathic loin-pain hematuria syndrome. Am J Kidney Dis 2006; 47:419〕 The prevalence of LPHS is estimated 〔http://www.uptodate.com/contents/loin-pain-hematuria-syndrome〕 at about 0.012 percent, which qualifies LPHS as a rare disease (prevalence less than 0.07 percent) according to the Rare Diseases Act of 2002. Those affected are usually young, with an average age of 31 years, and 70% to 80% are women.〔 If the estimated prevalence of 0.012% 〔http://www.uptodate.com/contents/loin-pain-hematuria-syndrom〕 is correct, a world population of 7 billion would imply approximately 840,000 cases worldwide. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Loin pain hematuria syndrome」の詳細全文を読む スポンサード リンク
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